Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy

Cisplatin remains an indispensable drug for the systemic treatment of many solid tumors. However, a major dose-limiting side-effect is ototoxicity. In some scenarios, such as treatment of germ cell tumors or adjuvant therapy of non-small cell lung cancer, cisplatin cannot be replaced without undue l...

Descripción completa

Detalles Bibliográficos
Autores principales: Tropitzsch, Anke, Müller, Marcus, Paquet-Durand, François, Mayer, Frank, Kopp, Hans-Georg, Schrattenholz, Andre, Müller, Andrea, Löwenheim, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746891/
https://www.ncbi.nlm.nih.gov/pubmed/31551715
http://dx.doi.org/10.3389/fncel.2019.00406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746891/
https://www.ncbi.nlm.nih.gov/pubmed/31551715
http://dx.doi.org/10.3389/fncel.2019.00406

Ejemplares similares