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Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy

Cisplatin remains an indispensable drug for the systemic treatment of many solid tumors. However, a major dose-limiting side-effect is ototoxicity. In some scenarios, such as treatment of germ cell tumors or adjuvant therapy of non-small cell lung cancer, cisplatin cannot be replaced without undue l...

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Detalles Bibliográficos
Autores principales:	Tropitzsch, Anke, Müller, Marcus, Paquet-Durand, François, Mayer, Frank, Kopp, Hans-Georg, Schrattenholz, Andre, Müller, Andrea, Löwenheim, Hubert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746891/ https://www.ncbi.nlm.nih.gov/pubmed/31551715 http://dx.doi.org/10.3389/fncel.2019.00406

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