Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6′,7′-Dihydroxybergamottin

Human cytochrome P450 3A4 (CYP3A4) is the most important drug-metabolizing enzyme. Some drugs and natural compounds can act as suicide (mechanism-based) inactivators of CYP3A4, leading to unanticipated drug-drug interactions, toxicity and therapeutic failures. Despite significant clinical and toxico...

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Detalles Bibliográficos
Autor principal: Sevrioukova, Irina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747129/
https://www.ncbi.nlm.nih.gov/pubmed/31480231
http://dx.doi.org/10.3390/ijms20174245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747129/
https://www.ncbi.nlm.nih.gov/pubmed/31480231
http://dx.doi.org/10.3390/ijms20174245

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