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Mutual Enhancement of Opioid and Adrenergic Receptors by Combinations of Opioids and Adrenergic Ligands Is Reflected in Molecular Complementarity of Ligands: Drug Development Possibilities

Crosstalk between opioid and adrenergic receptors is well characterized and due to interactions between second messenger systems, formation of receptor heterodimers, and extracellular allosteric binding regions. Both classes of receptors bind both sets of ligands. We propose here that receptor cross...

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Detalles Bibliográficos
Autores principales: Root-Bernstein, Robert, Churchill, Beth, Turke, Miah, Tiruttani Subhramanyam, Udaya K., Labahn, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747318/
https://www.ncbi.nlm.nih.gov/pubmed/31450631
http://dx.doi.org/10.3390/ijms20174137