Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells

P-glycoprotein (P-gp), which is encoded by the ATP-binding cassette (ABC) transporter subfamily B member 1 (ABCB1) gene, is one of the most pivotal ABC transporters that transport its substrates across the cell membrane. Its overexpression is one of the confirmed causes of multidrug resistance (MDR)...

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Detalles Bibliográficos
Autores principales: Cui, Qingbin, Cai, Chao-Yun, Wang, Jing-Quan, Zhang, Shuang, Gupta, Pranav, Ji, Ning, Yang, Yuqi, Dong, Xingduo, Yang, Dong-Hua, Chen, Zhe-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747525/
https://www.ncbi.nlm.nih.gov/pubmed/31443367
http://dx.doi.org/10.3390/ijms20174095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747525/
https://www.ncbi.nlm.nih.gov/pubmed/31443367
http://dx.doi.org/10.3390/ijms20174095

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