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Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

Arthropod-borne viruses are diverse pathogens and are often associated with human disease. These viruses span multiple genera, including flaviviruses, alphaviruses, and bunyaviruses. In a high-throughput drug screen, we found that tenovin-1 was antiviral against the flaviviruses Zika virus and dengu...

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Detalles Bibliográficos
Autores principales: Hackett, Brent A., Dittmar, Mark, Segrist, Elisha, Pittenger, Nathan, To, Julie, Griesman, Trevor, Gordesky-Gold, Beth, Schultz, David C., Cherry, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747726/
https://www.ncbi.nlm.nih.gov/pubmed/31289184
http://dx.doi.org/10.1128/mBio.01446-19