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Unexpected Mutations in HIV-1 That Confer Resistance to the Tat Inhibitor Didehydro-Cortistatin A
Didehydro-cortistatin A (dCA) is a human immunodeficiency virus type 1 (HIV-1) Tat inhibitor that functions by selectively binding to the RNA binding domain of Tat. In addition to inhibiting viral replication, dCA can drive HIV-1 into a state of “deep latency” in which latent viruses are refractory...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Microbiology
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747727/ https://www.ncbi.nlm.nih.gov/pubmed/31289189 http://dx.doi.org/10.1128/mBio.01547-19 |