Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells

Multifunctional signal transducer and activator of transcription (STAT) proteins play important roles in cancer. Here, we have shown that STAT6 is epigenetically silenced in some cases of malignant glioblastoma, which facilitates cancer cell survival in a hypoxic microenvironment. This downregulatio...

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Detalles Bibliográficos
Autores principales: Park, Soo Jung, Kim, Hyunmi, Kim, Se Hyuk, Joe, Eun-hye, Jou, Ilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747735/
https://www.ncbi.nlm.nih.gov/pubmed/31530290
http://dx.doi.org/10.1186/s40478-019-0798-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747735/
https://www.ncbi.nlm.nih.gov/pubmed/31530290
http://dx.doi.org/10.1186/s40478-019-0798-z

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