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PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism

Background: It was our intention to develop cathepsin B-sensitive nanoparticles for tumor-site-directed release. These nanoparticles should be able to release their payload as close to the tumor site with a decrease of off-target effects in mind. Cathepsin B, a lysosomal cysteine protease, is associ...

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Detalles Bibliográficos
Autores principales: Ehrsam, Daniel, Porta, Fabiola, Hussner, Janine, Seibert, Isabell, Meyer zu Schwabedissen, Henriette E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747961/
https://www.ncbi.nlm.nih.gov/pubmed/31484396
http://dx.doi.org/10.3390/ma12172836