BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X(L)

The impressive selectivity and efficacy of BH3 mimetics for treating cancer has largely been limited to BCL-2 dependent hematological malignancies. Most solid tumors depend on other anti-apoptotic proteins, including MCL-1, for survival. The recent description of S63845 as the first specific and pot...

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Detalles Bibliográficos
Autores principales: Greaves, Georgia, Milani, Mateus, Butterworth, Michael, Carter, Rachel J., Byrne, Dominic P., Eyers, Patrick A., Luo, Xu, Cohen, Gerald M., Varadarajan, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748112/
https://www.ncbi.nlm.nih.gov/pubmed/30185825
http://dx.doi.org/10.1038/s41418-018-0183-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748112/
https://www.ncbi.nlm.nih.gov/pubmed/30185825
http://dx.doi.org/10.1038/s41418-018-0183-7

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