Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regula...

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Detalles Bibliográficos
Autores principales: Orsini, Marion, Chateauvieux, Sébastien, Rhim, Jiyun, Gaigneaux, Anthoula, Cheillan, David, Christov, Christo, Dicato, Mario, Morceau, Franck, Diederich, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748125/
https://www.ncbi.nlm.nih.gov/pubmed/30546074
http://dx.doi.org/10.1038/s41418-018-0245-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748125/
https://www.ncbi.nlm.nih.gov/pubmed/30546074
http://dx.doi.org/10.1038/s41418-018-0245-x

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