Cargando…

BICD1 mediates HIF1α nuclear translocation in mesenchymal stem cells during hypoxia adaptation

Hypoxia inducible factor 1α (HIF1α) is a master regulator leading to metabolic adaptation, an essential physiological process to maintain the survival of stem cells under hypoxia. However, it is poorly understood how HIF1α translocates into the nucleus in stem cells under hypoxia. Here, we investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hyun Jik, Jung, Young Hyun, Oh, Ji Young, Choi, Gee Euhn, Chae, Chang Woo, Kim, Jun Sung, Lim, Jae Ryong, Kim, Seo Yihl, Lee, Sei-Jung, Seong, Je Kyung, Han, Ho Jae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748134/ https://www.ncbi.nlm.nih.gov/pubmed/30464225 http://dx.doi.org/10.1038/s41418-018-0241-1

Ejemplares similares

Role of HIF1α Regulatory Factors in Stem Cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

O-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Melatonin activates ABCA1 via the BiP/NRF1 pathway to suppress high-cholesterol-induced apoptosis of mesenchymal stem cells
por: Kim, Jun Sung, et al.
Publicado: (2021)

BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
por: Choi, Gee Euhn, et al.
Publicado: (2021)

Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1
por: Kim, Seo Yihl, et al.
Publicado: (2020)

Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
por: Lim, Jae Ryong, et al.
Publicado: (2020)

BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2017)

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death
por: Lee, Ki Hoon, et al.
Publicado: (2017)

High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells
por: Lee, Hyun Jik, et al.
Publicado: (2016)

Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR
por: Kim, Min Jeong, et al.
Publicado: (2023)

Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2–neuronal FGFR1 axis
por: Choi, Gee Euhn, et al.
Publicado: (2022)

Melatonin restores Muc2 depletion induced by V. vulnificus VvpM via melatonin receptor 2 coupling with Gαq
por: Lee, Young-Min, et al.
Publicado: (2020)

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways
por: Kim, Jeong Yeon, et al.
Publicado: (2017)

Glucocorticoid-mediated ER-mitochondria contacts reduce AMPA receptor and mitochondria trafficking into cell terminus via microtubule destabilization
por: Choi, Gee Euhn, et al.
Publicado: (2018)

Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission
por: Ko, So Hee, et al.
Publicado: (2017)

Author Correction: Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission
por: Ko, So Hee, et al.
Publicado: (2018)

Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts
por: Jung, Young Hyun, et al.
Publicado: (2022)

Regulation of Stem Cell Fate by ROS-mediated Alteration of Metabolism
por: Ryu, Jung Min, et al.
Publicado: (2015)

Melatonin inhibits apoptotic cell death induced by Vibrio vulnificus VvhA via melatonin receptor 2 coupling with NCF-1
por: Lee, Sei-Jung, et al.
Publicado: (2018)

Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2
por: Lee, Jae Eun, et al.
Publicado: (2019)

Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
por: Choi, Sik-Won, et al.
Publicado: (2016)

NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition
por: Joo, Hyun-Yoo, et al.
Publicado: (2023)

Dynamic Oxygen Conditions Promote the Translocation of HIF-1α to the Nucleus in Mouse Blastocysts
por: Choi, Jungwon, et al.
Publicado: (2021)

A Vibrio vulnificus VvpM Induces IL-1β Production Coupled with Necrotic Macrophage Death via Distinct Spatial Targeting by ANXA2
por: Lee, Sei-Jung, et al.
Publicado: (2017)

Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment
por: Gibson, James M, et al.
Publicado: (2022)

BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas
por: Huang, Shang-Pen, et al.
Publicado: (2021)

Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis
por: Kim, Jeong Sook, et al.
Publicado: (2019)

Porcine placenta hydrolysates regulate calcium disturbance in MC3T3-E1 osteoblastic cells
por: Lee, Hwa-Young, et al.
Publicado: (2016)

Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia
por: Oh, Eun-Taex, et al.
Publicado: (2016)

Netrin-1-Induced Stem Cell Bioactivity Contributes to the Regeneration of Injured Tissues via the Lipid Raft-Dependent Integrin α6β4 Signaling Pathway
por: Lee, Soo Sang, et al.
Publicado: (2016)

Hypoxia Antagonizes Glucose Deprivation on Interleukin 6 Expression in an Akt Dependent, but HIF-1/2α Independent Manner
por: Choi, Sung Ji, et al.
Publicado: (2013)

The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation
por: Kim, Inhyub, et al.
Publicado: (2020)

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures
por: Splinter, Daniël, et al.
Publicado: (2012)

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss
por: Hirsch, Yoel, et al.
Publicado: (2023)

Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice
por: Xiu, Jianbo, et al.
Publicado: (2022)

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
por: Koh, Han Seok, et al.
Publicado: (2015)

The key role of microtubules in hypoxia preconditioning-induced nuclear translocation of HIF-1α in rat cardiomyocytes
por: Guo, Hai, et al.
Publicado: (2017)

The mRNA transportome of the BicD/Egl transport machinery
por: Vazquez-Pianzola, Paula, et al.
Publicado: (2016)

The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction
por: Lee, Hwa-Young, et al.
Publicado: (2020)

Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation
por: Tsai, Meng-Han, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5nb12843f9pepkkl0nqj2fnb9p