Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice

Many acute myeloid leukaemias (AMLs) express high levels of BCL-2 and MCL-1, especially after therapy. To test the impact of these anti-apoptotic proteins on AML development and treatment, we used haemopoietic reconstitution to generate MLL-AF9 AMLs expressing BCL-2 or Mcl-1 transgenes. AMLs with el...

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Detalles Bibliográficos
Autores principales: Anstee, Natasha S., Bilardi, Rebecca A., Ng, Ashley P., Xu, Zhen, Robati, Mikara, Vandenberg, Cassandra J., Cory, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748137/
https://www.ncbi.nlm.nih.gov/pubmed/30470795
http://dx.doi.org/10.1038/s41418-018-0209-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748137/
https://www.ncbi.nlm.nih.gov/pubmed/30470795
http://dx.doi.org/10.1038/s41418-018-0209-1

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