By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

Drugs targeting various pro-survival BCL-2 family members (‘‘BH3 mimetics’’) have efficacy in hemopoietic malignancies, but the non-targeted pro-survival family members can promote resistance. Pertinently, the sensitivity of some tumor cell lines to BH3 mimetic ABT737, which targets BCL-2, BCL-XL, a...

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Detalles Bibliográficos
Autores principales: Tailler, Maximilien, Lindqvist, Lisa M., Gibson, Leonie, Adams, Jerry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748140/
https://www.ncbi.nlm.nih.gov/pubmed/30538285
http://dx.doi.org/10.1038/s41418-018-0244-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748140/
https://www.ncbi.nlm.nih.gov/pubmed/30538285
http://dx.doi.org/10.1038/s41418-018-0244-y

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