Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition

Oncogenic KRAS engages multiple effector pathways including the MAPK cascade to promote proliferation and survival of pancreatic cancer cells. KRAS-transformed cancer cells exhibit oncogene addiction to sustained activity of RAS for maintenance of malignant phenotypes. Previously, we have shown an e...

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Detalles Bibliográficos
Autores principales: Kent, Oliver A., Sandi, Maria-Jose, Rottapel, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Brief Report - Commissioned
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748365/
https://www.ncbi.nlm.nih.gov/pubmed/28656876
http://dx.doi.org/10.1080/21541248.2017.1337545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748365/
https://www.ncbi.nlm.nih.gov/pubmed/28656876
http://dx.doi.org/10.1080/21541248.2017.1337545

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