Engineering an anti-CD52 antibody for enhanced deamidation stability

Deamidation evaluation and mitigation is an important aspect of therapeutic antibody developability assessment. We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity-determining region 1, and risk mitigation through prote...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Huawei, Wei, Ronnie, Jaworski, Julie, Boudanova, Ekaterina, Hughes, Heather, VanPatten, Scott, Lund, Anders, Day, Jaime, Zhou, Yanfeng, McSherry, Tracey, Pan, Clark Q., Sendak, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748592/
https://www.ncbi.nlm.nih.gov/pubmed/31199181
http://dx.doi.org/10.1080/19420862.2019.1631117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748592/
https://www.ncbi.nlm.nih.gov/pubmed/31199181
http://dx.doi.org/10.1080/19420862.2019.1631117

Ejemplares similares