Binding symmetry and surface flexibility mediate antibody self-association

Solution stability is an important factor in the optimization of engineered biotherapeutic candidates such as monoclonal antibodies because of its possible effects on manufacturability, pharmacology, efficacy and safety. A detailed atomic understanding of the mechanisms governing self-association of...

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Detalles Bibliográficos
Autores principales: Schrag, Joseph D., Picard, Marie-Ève, Gaudreault, Francis, Gagnon, Louis-Patrick, Baardsnes, Jason, Manenda, Mahder S., Sheff, Joey, Deprez, Christophe, Baptista, Cassio, Hogues, Hervé, Kelly, John F., Purisima, Enrico O., Shi, Rong, Sulea, Traian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748613/
https://www.ncbi.nlm.nih.gov/pubmed/31318308
http://dx.doi.org/10.1080/19420862.2019.1632114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748613/
https://www.ncbi.nlm.nih.gov/pubmed/31318308
http://dx.doi.org/10.1080/19420862.2019.1632114

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