Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

The neonatal Fc receptor (FcRn) promotes antibody recycling through rescue from normal lysosomal degradation. The binding interaction is pH-dependent with high affinity at low pH, but not under physiological pH conditions. Here, we combined rational design and saturation mutagenesis to generate nove...

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Detalles Bibliográficos
Autores principales: Mackness, Brian C., Jaworski, Julie A., Boudanova, Ekaterina, Park, Anna, Valente, Delphine, Mauriac, Christine, Pasquier, Olivier, Schmidt, Thorsten, Kabiri, Mostafa, Kandira, Abdullah, Radošević, Katarina, Qiu, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748615/
https://www.ncbi.nlm.nih.gov/pubmed/31216930
http://dx.doi.org/10.1080/19420862.2019.1633883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748615/
https://www.ncbi.nlm.nih.gov/pubmed/31216930
http://dx.doi.org/10.1080/19420862.2019.1633883

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