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Characterization of a single reporter-gene potency assay for T-cell-dependent bispecific molecules

T-cell-dependent bispecific antibodies (TDBs) are promising cancer immunotherapies that recruit patients’ T cells to kill cancer cells. There are many TDBs in clinical trials, demonstrating their widely recognized therapeutic potential. However, their complex, multi-step mechanism of action (MoA), w...

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Detalles Bibliográficos
Autores principales: Lee, Ho Young, Register, Ames, Shim, Jeongsup, Contreras, Edward, Wu, Qiang, Jiang, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748617/
https://www.ncbi.nlm.nih.gov/pubmed/31348721
http://dx.doi.org/10.1080/19420862.2019.1640548