Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions

Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer’s disease and other dementias(1), yet the physiological state of tau molecules within cells remains unclear. Using single molecule imaging, we directly observe that the mic...

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Detalles Bibliográficos
Autores principales: Tan, Ruensern, Lam, Aileen J., Tan, Tracy, Han, Jisoo, Nowakowski, Dan W., Vershinin, Michael, Simó, Sergi, Ori-McKenney, Kassandra M., McKenney, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748660/
https://www.ncbi.nlm.nih.gov/pubmed/31481790
http://dx.doi.org/10.1038/s41556-019-0375-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748660/
https://www.ncbi.nlm.nih.gov/pubmed/31481790
http://dx.doi.org/10.1038/s41556-019-0375-5

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