Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

Surfactant protein B (SFTPB) deficiency is a fatal disease affecting newborn infants. Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. Here we show the differentiation of patient s...

Descripción completa

Detalles Bibliográficos
Autores principales: Leibel, Sandra Lawrynowicz, Winquist, Alicia, Tseu, Irene, Wang, Jinxia, Luo, Daochun, Shojaie, Sharareh, Nathan, Neal, Snyder, Evan, Post, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748939/
https://www.ncbi.nlm.nih.gov/pubmed/31530844
http://dx.doi.org/10.1038/s41598-019-49696-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748939/
https://www.ncbi.nlm.nih.gov/pubmed/31530844
http://dx.doi.org/10.1038/s41598-019-49696-8

Ejemplares similares