TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression

SRY is the master regulator of male sex determination in eutherian mammals. In mice, Sry expression is transcriptionally and epigenetically controlled in a developmental stage-specific manner. The Sry promoter undergoes demethylation in embryonic gonadal somatic cells at the sex-determining period....

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Detalles Bibliográficos
Autores principales: Okashita, Naoki, Kuroki, Shunsuke, Maeda, Ryo, Tachibana, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748950/
https://www.ncbi.nlm.nih.gov/pubmed/31530896
http://dx.doi.org/10.1038/s41598-019-50058-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748950/
https://www.ncbi.nlm.nih.gov/pubmed/31530896
http://dx.doi.org/10.1038/s41598-019-50058-7

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