Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber’s Congenital Amaurosis Patient With Novel RPE65 Mutations

RPE65-associated Leber congenital amaurosis (LCA) is one of highly heterogeneous, early onset, severe retinal dystrophies with at least 130 gene mutation sites identified. Their pathogenicity has not been directly clarified due to lack of diseased cells. Here, we generated human-induced pluripotent...

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Detalles Bibliográficos
Autores principales: Li, Guilan, Gao, Guanjie, Wang, Panfeng, Song, Xiaojing, Xu, Ping, Xie, Bingbing, Zhou, Tiancheng, Pan, Guangjin, Peng, Fuhua, Zhang, Qingjiong, Ge, Jian, Zhong, Xiufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749091/
https://www.ncbi.nlm.nih.gov/pubmed/31572124
http://dx.doi.org/10.3389/fnmol.2019.00212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749091/
https://www.ncbi.nlm.nih.gov/pubmed/31572124
http://dx.doi.org/10.3389/fnmol.2019.00212

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