The huntingtin inclusion is a dynamic phase-separated compartment

Inclusions of disordered protein are a characteristic feature of most neurodegenerative diseases, including Huntington’s disease. Huntington’s disease is caused by expansion of a polyglutamine tract in the huntingtin protein; mutant huntingtin protein (mHtt) is unstable and accumulates in large intr...

Descripción completa

Detalles Bibliográficos
Autores principales: Aktar, Fahmida, Burudpakdee, Chakkapong, Polanco, Mercedes, Pei, Sen, Swayne, Theresa C, Lipke, Peter N, Emtage, Lesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749095/
https://www.ncbi.nlm.nih.gov/pubmed/31527136
http://dx.doi.org/10.26508/lsa.201900489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749095/
https://www.ncbi.nlm.nih.gov/pubmed/31527136
http://dx.doi.org/10.26508/lsa.201900489

Ejemplares similares