Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines

A new synthetic route to N-alkyl-2-acylazetidines was developed through a highly stereoselective addition of organolithiums to N-alkyl-2-oxazolinylazetidines followed by acidic hydrolysis of the resulting oxazolidine intermediates. This study revealed an unusual reactivity of the C=N bond of the oxa...

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Detalles Bibliográficos
Autores principales: Musci, Pantaleo, Colella, Marco, Fanelli, Flavio, Altomare, Angela, Pisano, Luisa, Carlucci, Claudia, Luisi, Renzo, Degennaro, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749145/
https://www.ncbi.nlm.nih.gov/pubmed/31572708
http://dx.doi.org/10.3389/fchem.2019.00614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749145/
https://www.ncbi.nlm.nih.gov/pubmed/31572708
http://dx.doi.org/10.3389/fchem.2019.00614

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