Tracing Potential Covalent Inhibitors of an E3 Ubiquitin Ligase through Target-Focused Modelling

The Nedd4-1 E3 Ubiquitin ligase has been implicated in multiple disease conditions due its overexpression. Although the enzyme may be targeted both covalently and non-covalently, minimal studies provide effective inhibitors against it. Recently, research has focused on covalent inhibitors based on t...

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Detalles Bibliográficos
Autores principales: Bjij, Imane, Ramharack, Pritika, Khan, Shama, Cherqaoui, Driss, Soliman, Mahmoud E. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749425/
https://www.ncbi.nlm.nih.gov/pubmed/31466292
http://dx.doi.org/10.3390/molecules24173125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749425/
https://www.ncbi.nlm.nih.gov/pubmed/31466292
http://dx.doi.org/10.3390/molecules24173125

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