Cargando…
Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity
Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance. In that regard, flexible nucleoside analogues know...
Autores principales: | Yates, Mary K., Chatterjee, Payel, Flint, Mike, Arefeayne, Yafet, Makuc, Damjan, Plavec, Janez, Spiropoulou, Christina F., Seley-Radtke, Katherine L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749450/ https://www.ncbi.nlm.nih.gov/pubmed/31480658 http://dx.doi.org/10.3390/molecules24173184 |
Ejemplares similares
-
Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity
por: Peters, Hannah L., et al.
Publicado: (2015) -
Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues
por: Gazivoda, Tatjana, et al.
Publicado: (2008) -
Methoxymethyl (MOM) Group Nitrogen Protection of Pyrimidines Bearing C-6 Acyclic Side-Chains
por: Kraljević, Tatjana Gazivoda, et al.
Publicado: (2011) -
Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1
por: Ku, Therese, et al.
Publicado: (2019) -
Flex-nucleoside analogues – Novel therapeutics against filoviruses
por: Yates, Mary K., et al.
Publicado: (2017)