Design, Synthesis and Molecular Docking Analysis of Flavonoid Derivatives as Potential Telomerase Inhibitors

Based on the structural scaffolds of natural products, two series of flavonoid derivatives, for a total of twelve compounds, were designed and synthesized as potential human telomerase inhibitors. Using a modified TRAP-PCR assay, compound 5c exhibited the most potent inhibitory activity against huma...

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Detalles Bibliográficos
Autores principales: Fan, Zhan-Fang, Ho, Sai-Tim, Wen, Rui, Fu, Ya, Zhang, Lei, Wang, Jian, Hu, Chun, Shaw, Pang-Chui, Liu, Yang, Cheng, Mao-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749477/
https://www.ncbi.nlm.nih.gov/pubmed/31480619
http://dx.doi.org/10.3390/molecules24173180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749477/
https://www.ncbi.nlm.nih.gov/pubmed/31480619
http://dx.doi.org/10.3390/molecules24173180

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