The Role of Active-Site Residues Phe98, His239, and Arg243 in DNA Binding and in the Catalysis of Human Uracil–DNA Glycosylase SMUG1

Human SMUG1 (hSMUG1) hydrolyzes the N-glycosidic bond of uracil and some uracil lesions formed in the course of epigenetic regulation. Despite the functional importance of hSMUG1 in the DNA repair pathway, the damage recognition mechanism has been elusive to date. In the present study, our objective...

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Detalles Bibliográficos
Autores principales: Iakovlev, Danila A., Alekseeva, Irina V., Vorobjev, Yury N., Kuznetsov, Nikita A., Fedorova, Olga S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749576/
https://www.ncbi.nlm.nih.gov/pubmed/31466351
http://dx.doi.org/10.3390/molecules24173133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749576/
https://www.ncbi.nlm.nih.gov/pubmed/31466351
http://dx.doi.org/10.3390/molecules24173133

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