Combined Anti-inflammatory and Neuroprotective Treatments Have the Potential to Impact Disease Phenotypes in Cln3(−/−) Mice

Batten disease, or juvenile NCL, is a fatal neurodegenerative disorder that occurs due to mutations in the CLN3 gene. Because the function of CLN3 remains unclear, experimental therapies for JNCL have largely concentrated upon the targeting of downstream pathomechanisms. Neuron loss is preceded by l...

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Detalles Bibliográficos
Autores principales: Tarczyluk-Wells, Marta A., Salzlechner, Christoph, Najafi, Allison R., Lim, Ming J., Smith, David, Platt, Frances M., Williams, Brenda P., Cooper, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749847/
https://www.ncbi.nlm.nih.gov/pubmed/31572287
http://dx.doi.org/10.3389/fneur.2019.00963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749847/
https://www.ncbi.nlm.nih.gov/pubmed/31572287
http://dx.doi.org/10.3389/fneur.2019.00963

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