Cargando…

Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy

BACKGROUND: Diabetic nephropathy (DN) is a progressive microvascular complication of diabetes mellitus (DM), driven largely by podocyte apoptosis. The cysteine protease Calpain 10 is known to augment apoptosis and necrosis, and is a potential therapeutic target in DN. METHODS: Type 2 diabetes was in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Tao, Gao, Yanbin, Wang, Xiaolei, Shi, Yimin, Xu, Jiayi, Wu, Bingjie, He, Jiaxin, Li, Yimeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750010/ https://www.ncbi.nlm.nih.gov/pubmed/31571956 http://dx.doi.org/10.2147/DMSO.S217924

Ejemplares similares

Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKT/GSK3 β/β-Catenin Pathway by Restoring Autophagic Activity
por: Shi, Yimin, et al.
Publicado: (2020)

Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF-κB/NLRP3 Axis
por: Wang, Tao, et al.
Publicado: (2020)

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy
por: Tian, Nianxiu, et al.
Publicado: (2018)

Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT–NF-κB p65 axis
por: Wang, Xiaolei, et al.
Publicado: (2019)

Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation
por: Xu, Jiayi, et al.
Publicado: (2022)

Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury
por: Ding, Fangrui, et al.
Publicado: (2016)

Metadherin facilitates podocyte apoptosis in diabetic nephropathy
por: Liu, Wen-Ting, et al.
Publicado: (2016)

Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade
por: Ding, Yin, et al.
Publicado: (2021)

Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes
por: Jiang, Jun, et al.
Publicado: (2018)

Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice
por: Wang, Xiaolei, et al.
Publicado: (2018)

MicroRNAs in Podocyte Injury in Diabetic Nephropathy
por: Ishii, Hiroki, et al.
Publicado: (2020)

MicroRNAs for podocyte injury in diabetic nephropathy
por: Morishita, Yoshiyuki
Publicado: (2021)

Mechanisms of podocyte injury and implications for diabetic nephropathy
por: Barutta, Federica, et al.
Publicado: (2022)

Anhuienoside C Attenuates Podocyte Injury in Diabetic Nephropathy Rats
por: Wang, Chengjian, et al.
Publicado: (2020)

Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury
por: Tian, Xuefei, et al.
Publicado: (2020)

Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis
por: He, Jiaxin, et al.
Publicado: (2023)

Drug Targets for Oxidative Podocyte Injury in Diabetic Nephropathy
por: Bhatti, Adnan Bashir, et al.
Publicado: (2015)

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes
por: Li, Xueling, et al.
Publicado: (2020)

Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling
por: Liu, Yiqi, et al.
Publicado: (2022)

Role of Calpain in Apoptosis
por: Momeni, Hamid Reza
Publicado: (2011)

Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy
por: Ma, Ruixia, et al.
Publicado: (2021)

The Study of Angptl4-Modulated Podocyte Injury in IgA Nephropathy
por: Jia, Sha, et al.
Publicado: (2021)

Editorial: Podocyte Pathology and Nephropathy
por: Lewko, Barbara, et al.
Publicado: (2015)

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy
por: Liu, J, et al.
Publicado: (2016)

Connexin 43-autophagy loop in the podocyte injury of diabetic nephropathy
por: Ji, Jialing, et al.
Publicado: (2019)

Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
por: Braun, Fabian, et al.
Publicado: (2023)

IgA nephropathy with podocytic infolding glomerulopathy
por: Wang, Zhouyang, et al.
Publicado: (2023)

Long noncoding RNA MEG3 suppresses podocyte injury in diabetic nephropathy by inactivating Wnt/β-catenin signaling
por: Che, Xiajing, et al.
Publicado: (2019)

Human podocyte injury in the early course of hypertensive renal injury
por: Sun, Da, et al.
Publicado: (2019)

Enhanced Orai1-mediated store-operated Ca(2+) channel/calpain signaling contributes to high glucose-induced podocyte injury
por: Tao, Yu, et al.
Publicado: (2022)

Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy
por: MA, RUIXIA, et al.
Publicado: (2013)

Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats
por: Cui, Fangqiang, et al.
Publicado: (2016)

Catalpol Ameliorates Podocyte Injury by Stabilizing Cytoskeleton and Enhancing Autophagy in Diabetic Nephropathy
por: Chen, Yan, et al.
Publicado: (2019)

Editorial: Podocyte Pathology and Nephropathy—An Update
por: Lehtonen, Sanna, et al.
Publicado: (2019)

Epigenetic Alterations in Podocytes in Diabetic Nephropathy
por: Sugita, Erina, et al.
Publicado: (2021)

Podocyte puzzle: IgA nephropathy
por: Bharati, Joyita, et al.
Publicado: (2023)

Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy
por: Suk Kang, Jeong, et al.
Publicado: (2021)

Mitofusin2 expression is associated with podocyte injury in IgA nephropathy
por: Tang, Xuanli, et al.
Publicado: (2023)

Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy
por: Ma, Yiqiong, et al.
Publicado: (2019)

Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy
por: Liu, Feng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_flh7grc8071lfj0aqtbnvcv0ke