Direct Nkx2‐5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

During cardiogenesis, most myocytes arise from cardiac progenitors expressing the transcription factors Isl1 and Nkx2‐5. Here, we show that a direct repression of Isl1 by Nkx2‐5 is necessary for proper development of the ventricular myocardial lineage. Overexpression of Nkx2‐5 in mouse embryonic ste...

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Detalles Bibliográficos
Autores principales: Dorn, Tatjana, Goedel, Alexander, Lam, Jason T., Haas, Jessica, Tian, Qinghai, Herrmann, Franziska, Bundschu, Karin, Dobreva, Gergana, Schiemann, Matthias, Dirschinger, Ralf, Guo, Yanchun, Kühl, Susanne J., Sinnecker, Daniel, Lipp, Peter, Laugwitz, Karl-Ludwig, Kühl, Michael, Moretti, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750130/
https://www.ncbi.nlm.nih.gov/pubmed/25524439
http://dx.doi.org/10.1002/stem.1923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750130/
https://www.ncbi.nlm.nih.gov/pubmed/25524439
http://dx.doi.org/10.1002/stem.1923

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