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Direct Nkx2‐5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity
During cardiogenesis, most myocytes arise from cardiac progenitors expressing the transcription factors Isl1 and Nkx2‐5. Here, we show that a direct repression of Isl1 by Nkx2‐5 is necessary for proper development of the ventricular myocardial lineage. Overexpression of Nkx2‐5 in mouse embryonic ste...
Autores principales: | Dorn, Tatjana, Goedel, Alexander, Lam, Jason T., Haas, Jessica, Tian, Qinghai, Herrmann, Franziska, Bundschu, Karin, Dobreva, Gergana, Schiemann, Matthias, Dirschinger, Ralf, Guo, Yanchun, Kühl, Susanne J., Sinnecker, Daniel, Lipp, Peter, Laugwitz, Karl-Ludwig, Kühl, Michael, Moretti, Alessandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750130/ https://www.ncbi.nlm.nih.gov/pubmed/25524439 http://dx.doi.org/10.1002/stem.1923 |
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