Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice

AMP-activated protein kinase (AMPK) is a multifunctional kinase that negatively regulates the mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) signaling, two signaling pathways linked to pain promotion after injury, such as surgical incision. AMPK can be activated d...

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Detalles Bibliográficos
Autores principales: Inyang, Kufreobong E., Burton, Michael D., Szabo-Pardi, Thomas, Wentworth, Emma, McDougal, Timothy A., Ramirez, Eric D., Pradhan, Grishma, Dussor, Gregory, Price, Theodore J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Neuropharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750189/
https://www.ncbi.nlm.nih.gov/pubmed/31324647
http://dx.doi.org/10.1124/jpet.119.258400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750189/
https://www.ncbi.nlm.nih.gov/pubmed/31324647
http://dx.doi.org/10.1124/jpet.119.258400

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