Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression

Amino acid (AA) metabolism is involved in diverse cellular functions, including cell survival and growth, however it remains unclear how it regulates normal hematopoiesis versus leukemogenesis. Here, we report that knockout of Slc1a5 (ASCT2), a transporter of neutral AAs, especially glutamine, resul...

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Detalles Bibliográficos
Autores principales: Ni, Fang, Yu, Wen-Mei, Li, Zhiguo, Graham, Douglas K., Jin, Lingtao, Kang, Sumin, Rossi, Michael R., Li, Shiyong, Broxmeyer, Hal E., Qu, Cheng-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750232/
https://www.ncbi.nlm.nih.gov/pubmed/31535081
http://dx.doi.org/10.1038/s42255-019-0039-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750232/
https://www.ncbi.nlm.nih.gov/pubmed/31535081
http://dx.doi.org/10.1038/s42255-019-0039-6

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