Profiling allele specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage

One fundamental, but understudied mechanism of gene regulation in disease is allele specific expression (ASE), the preferential expression of one allele. We leveraged RNA-seq from human brain to assess ASE in autism spectrum disorder (ASD). When ASE is observed in ASD, the allele with lower populati...

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Detalles Bibliográficos
Autores principales: Lee, Changhoon, Kang, Eun Yong, Gandal, Michael J., Eskin, Eleazar, Geschwind, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750256/
https://www.ncbi.nlm.nih.gov/pubmed/31455884
http://dx.doi.org/10.1038/s41593-019-0461-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750256/
https://www.ncbi.nlm.nih.gov/pubmed/31455884
http://dx.doi.org/10.1038/s41593-019-0461-9

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