Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro

BACKGROUND: Cytochrome P450 3A4 (CYP3A4) appears to be genetically polymorphic, which in turn contributes to interindividual variability in response to therapeutic drugs. Loperamide, identified as a CYP3A4 substrate, is prone to misuse and abuse and has high risks of life-threatening cardiotoxicity....

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Detalles Bibliográficos
Autores principales: Lin, Qian-Meng, Li, Ying-Hui, Liu, Qian, Pang, Ni-Hong, Xu, Ren-Ai, Cai, Jian-Ping, Hu, Guo-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750855/
https://www.ncbi.nlm.nih.gov/pubmed/31571937
http://dx.doi.org/10.2147/IDR.S215129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750855/
https://www.ncbi.nlm.nih.gov/pubmed/31571937
http://dx.doi.org/10.2147/IDR.S215129

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