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Effect of glutaminase inhibition on cancer-induced bone pain

PURPOSE: The complex nature of cancer-induced bone pain (CIBP) has led to investigation into cancer-targeted therapies. This has involved targeting glutamate release from the tumor, secreted as a byproduct of antioxidant responses and metabolic disruption. Cancer cells undergo many metabolic changes...

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Detalles Bibliográficos
Autores principales: Fazzari, Jennifer, Singh, Gurmit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750878/
https://www.ncbi.nlm.nih.gov/pubmed/31571981
http://dx.doi.org/10.2147/BCTT.S215655