De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives

[Image: see text] Targeted protein degradation via cereblon (CRBN), a substrate receptor of an E3 ubiquitin ligase complex, is an increasingly important strategy in various clinical settings, in which the substrate specificity of CRBN is altered via the binding of small-molecule effectors. To date,...

Descripción completa

Detalles Bibliográficos
Autores principales: Heim, Christopher, Pliatsika, Dimanthi, Mousavizadeh, Farnoush, Bär, Kerstin, Hernandez Alvarez, Birte, Giannis, Athanassios, Hartmann, Marcus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750895/
https://www.ncbi.nlm.nih.gov/pubmed/31251063
http://dx.doi.org/10.1021/acs.jmedchem.9b00454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750895/
https://www.ncbi.nlm.nih.gov/pubmed/31251063
http://dx.doi.org/10.1021/acs.jmedchem.9b00454

Ejemplares similares