Accelerated degradation of cFLIP(L) and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis

Plant-derived lignans have numerous biological effects including anti-tumor and anti-inflammatory activities. Screening of purified constituents of Rubia philippinensis from human glioblastoma cells resistant to TNF-related apoptosis-inducing ligand (TRAIL) has suggested that the lignan pinoresinol...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, So-Ra, Quan, Khong Trong, Byun, Hee Sun, Park, InWha, Kang, Kidong, Piao, Xuezhe, Ju, Eunjin, Ro, Hyunju, Na, MinKyun, Hur, Gang Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751165/
https://www.ncbi.nlm.nih.gov/pubmed/31534206
http://dx.doi.org/10.1038/s41598-019-49909-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751165/
https://www.ncbi.nlm.nih.gov/pubmed/31534206
http://dx.doi.org/10.1038/s41598-019-49909-0

Ejemplares similares