An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy

The paralogous scaffold proteins axin and conductin/axin2 are key factors in the negative regulation of the Wnt pathway transcription factor β-catenin, thereby representing interesting targets for signaling regulation. Polymerization of axin proteins is essential for their activity in suppressing Wn...

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Detalles Bibliográficos
Autores principales: Bernkopf, Dominic B., Brückner, Martina, Hadjihannas, Michel V., Behrens, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751202/
https://www.ncbi.nlm.nih.gov/pubmed/31534175
http://dx.doi.org/10.1038/s41467-019-12203-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751202/
https://www.ncbi.nlm.nih.gov/pubmed/31534175
http://dx.doi.org/10.1038/s41467-019-12203-8

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