Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes

ATP-binding cassette (ABC) transporters prevent the access of pharmacological compounds to the ischemic brain, thereby impeding the efficacy of stroke therapies. ABC transporters can be deactivated by selective inhibitors, which potently increase the brain accumulation of drugs. Concerns have been r...

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Detalles Bibliográficos
Autores principales: Manrique-Castano, Daniel, Sardari, Maryam, Silva de Carvalho, Tayana, Doeppner, Thorsten R., Popa-Wagner, Aurel, Kleinschnitz, Christoph, Chan, Andrew, Hermann, Dirk M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751309/
https://www.ncbi.nlm.nih.gov/pubmed/31572128
http://dx.doi.org/10.3389/fncel.2019.00412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751309/
https://www.ncbi.nlm.nih.gov/pubmed/31572128
http://dx.doi.org/10.3389/fncel.2019.00412

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