Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats

BACKGROUND: p66Shc, a Src homologue and collagen homologue (Shc) adaptor protein, mediates oxidative stress signaling. The p66Shc-null mice have increased lifespan and enhanced resistance to oxidative stress. Studies have also indicated its potential role in inner ear aging, which can lead to deafne...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Cong, Wu, Xuewen, Zhou, Ruoyu, Zhang, Hao, Zhou, Yulai, Wang, Xinxing, Feng, Yong, Mei, Lingyun, He, Chufeng, Cai, Xinzhang, Wu, Lisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751335/
https://www.ncbi.nlm.nih.gov/pubmed/31686782
http://dx.doi.org/10.2147/DDDT.S214918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751335/
https://www.ncbi.nlm.nih.gov/pubmed/31686782
http://dx.doi.org/10.2147/DDDT.S214918

Ejemplares similares