Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats

BACKGROUND: p66Shc, a Src homologue and collagen homologue (Shc) adaptor protein, mediates oxidative stress signaling. The p66Shc-null mice have increased lifespan and enhanced resistance to oxidative stress. Studies have also indicated its potential role in inner ear aging, which can lead to deafne...

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Detalles Bibliográficos
Autores principales: Hao, Cong, Wu, Xuewen, Zhou, Ruoyu, Zhang, Hao, Zhou, Yulai, Wang, Xinxing, Feng, Yong, Mei, Lingyun, He, Chufeng, Cai, Xinzhang, Wu, Lisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751335/
https://www.ncbi.nlm.nih.gov/pubmed/31686782
http://dx.doi.org/10.2147/DDDT.S214918

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