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A Bayesian non-inferiority approach using experts’ margin elicitation – application to the monitoring of safety events
BACKGROUND: When conducing Phase-III trial, regulatory agencies and investigators might want to get reliable information about rare but serious safety outcomes during the trial. Bayesian non-inferiority approaches have been developed, but commonly utilize historical placebo-controlled data to define...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751616/ https://www.ncbi.nlm.nih.gov/pubmed/31533631 http://dx.doi.org/10.1186/s12874-019-0826-5 |