DNA G-Quadruplexes Activate Heme for Robust Catalysis of Carbene Transfer Reactions

[Image: see text] Guanine-rich single-stranded DNAs and RNAs that fold into G-quadruplexes (GQs) are known to complex tightly with Fe(II)-heme and Fe(III)-heme (hemin), ubiquitous cellular cofactors. Heme–GQ (DNA) complexes, known as heme·DNAzymes, are able to utilize hydrogen peroxide as an oxidant...

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Detalles Bibliográficos
Autores principales: Ibrahim, Hanadi, Mulyk, Paul, Sen, Dipankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751727/
https://www.ncbi.nlm.nih.gov/pubmed/31552375
http://dx.doi.org/10.1021/acsomega.9b02305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751727/
https://www.ncbi.nlm.nih.gov/pubmed/31552375
http://dx.doi.org/10.1021/acsomega.9b02305

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