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DNA G-Quadruplexes Activate Heme for Robust Catalysis of Carbene Transfer Reactions
[Image: see text] Guanine-rich single-stranded DNAs and RNAs that fold into G-quadruplexes (GQs) are known to complex tightly with Fe(II)-heme and Fe(III)-heme (hemin), ubiquitous cellular cofactors. Heme–GQ (DNA) complexes, known as heme·DNAzymes, are able to utilize hydrogen peroxide as an oxidant...
Autores principales: | Ibrahim, Hanadi, Mulyk, Paul, Sen, Dipankar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751727/ https://www.ncbi.nlm.nih.gov/pubmed/31552375 http://dx.doi.org/10.1021/acsomega.9b02305 |
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