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Evolution of resistance mechanisms and biological characteristics of rifampicin-resistant Staphylococcus aureus strains selected in vitro
BACKGROUND: We aimed to determine the evolutionary pathways of rifampicin resistance in Staphylococcus aureus, and the impact of resistance mutations in the rpoB gene on fitness. METHODS: Three clinical strains and one reference strain were used to select for rifampicin-resistant S. aureus variants....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751903/ https://www.ncbi.nlm.nih.gov/pubmed/31533633 http://dx.doi.org/10.1186/s12866-019-1573-9 |