The functional impact of variants of uncertain significance in BRCA2

PURPOSE: Genetic testing has uncovered large numbers of variants in the BRCA2 gene for which the clinical significance is unclear. Cancer risk prediction of these variants of uncertain significance (VUS) can be improved by reliable assessment of the extent of impairment of the tumor suppressor funct...

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Detalles Bibliográficos
Autores principales: Mesman, Romy L. S., Calléja, Fabienne M. G. R., Hendriks, Giel, Morolli, Bruno, Misovic, Branislav, Devilee, Peter, van Asperen, Christi J., Vrieling, Harry, Vreeswijk, Maaike P. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752316/
https://www.ncbi.nlm.nih.gov/pubmed/29988080
http://dx.doi.org/10.1038/s41436-018-0052-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752316/
https://www.ncbi.nlm.nih.gov/pubmed/29988080
http://dx.doi.org/10.1038/s41436-018-0052-2

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