Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

PURPOSE: Severe hematotoxicity in patients with thiopurine therapy has been associated with genetic polymorphisms in the thiopurine S-methyltransferase (TPMT). While TPMT genetic testing is clinically implemented for dose individualization, alterations in the nudix hydrolase 15 (NUDT15) emerged as i...

Descripción completa

Detalles Bibliográficos
Autores principales: Schaeffeler, Elke, Jaeger, Simon U., Klumpp, Verena, Yang, Jun J., Igel, Svitlana, Hinze, Laura, Stanulla, Martin, Schwab, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752748/
https://www.ncbi.nlm.nih.gov/pubmed/30728528
http://dx.doi.org/10.1038/s41436-019-0448-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752748/
https://www.ncbi.nlm.nih.gov/pubmed/30728528
http://dx.doi.org/10.1038/s41436-019-0448-7

Ejemplares similares